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CGAP:NCBI癌症基因组剖析计划

CGAP:NCBI癌症基因组剖析计划

CGAP,The Cancer Genome Anatomy Project

CGAP简介

The goal of the NCI’s Cancer Genome Anatomy Project is to determine the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient. By collaborating with scientists worldwide, CGAP seeks to increase its scientific expertise and expand its databases for the benefit of all cancer researchers.

CGAP计划是一项由NCI建立和主持的交叉学科的计划,用来产生用于解码肿瘤细胞的分子结构所需的信息和技术工具。CGAP被分为五个互补的自主部分,每一个都有它自己的目的,信息学工具和资源。The Human Tumor Gene Index (hTGI)人类肿瘤基因索引指明了在人类肿瘤发生过程中的基因表达。Molecular Profiling (MP)分子表达谱展示了用前列腺作为例子来从分子水平分析人类组织样品的概念。The Cancer Chromosome Aberration Project (CCAP)癌症染色体变异计划(CCAP)描述了同恶性转移相关的染色体改变。The Genetic Annotation Index (GAI)遗传注解索引指明和描绘了同癌症相关的多态性。The Mouse Tumor Gene Index (mTGI)小鼠肿瘤基因索引(mTGI)确定了在小鼠肿瘤发生过程中的基因表达。 阅读更多

乳癌数据库(Breast Cancer Database)

The database contains comprehensive listing of “molecular alterations associated with Breast Cancer”.

It includes information related to molecular alterations at the genome, mRNA and protein levels. The data can be queried or browsed at DNA, mRNA and Protein levels.

The entries are linked to the Human Protein Reference Database (HPRD) for manually curated protein annotation; as well as to ONCOMINE, OMIM, Swiss-Prot and GeneCards.

http://www.breastcancerdatabase.org/ 阅读更多

MoKCa:癌症相关突变激酶信息数据库

MoKCa:癌症相关突变激酶信息数据库

当人类罹患癌症时,蛋白激酶家族成员是发生基因突变最多的一类基因。这些发生突变的激酶基因和被激活的激酶基因也是抗癌治疗最有效的作用靶点。

MoKCa数据库http://strubiol.icr.ac.uk/extra/mokca)是一个有关癌症相关突变激酶信息的数据库,库中收录了大量与突变激酶基因相关的结构注释信息和功能注释信息,以及当这些激酶发生突变时会产生怎样的结果的预测信息。肿瘤组织和肿瘤细胞系体细胞突变数据被标记在相应的蛋白质晶体结构域上。在蛋白质结构域象形图上以及蛋白质3D结构图上还对发生突变的氨基酸位点进行了突出标记。 阅读更多