The database contains comprehensive listing of “molecular alterations associated with Breast Cancer”.

It includes information related to molecular alterations at the genome, mRNA and protein levels. The data can be queried or browsed at DNA, mRNA and Protein levels.

The entries are linked to the Human Protein Reference Database (HPRD) for manually curated protein annotation; as well as to ONCOMINE, OMIM, Swiss-Prot and GeneCards.

http://www.breastcancerdatabase.org/ Continue Reading

当人类罹患癌症时，蛋白激酶家族成员是发生基因突变最多的一类基因。这些发生突变的激酶基因和被激活的激酶基因也是抗癌治疗最有效的作用靶点。

MoKCa数据库（http://strubiol.icr.ac.uk/extra/mokca）是一个有关癌症相关突变激酶信息的数据库，库中收录了大量与突变激酶基因相关的结构注释信息和功能注释信息，以及当这些激酶发生突变时会产生怎样的结果的预测信息。肿瘤组织和肿瘤细胞系体细胞突变数据被标记在相应的蛋白质晶体结构域上。在蛋白质结构域象形图上以及蛋白质3D结构图上还对发生突变的氨基酸位点进行了突出标记。 Continue Reading