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	<title>柳城 &#187; Entrez</title>
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		<title>Entrez系统扩展组件更有利于检索</title>
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		<pubDate>Fri, 19 Jun 2009 09:05:26 +0000</pubDate>
		<dc:creator>柳城</dc:creator>
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			<content:encoded><![CDATA[<h3><span class='wp_keywordlink'><a href="http://liucheng.name/entrez/" title="Entrez" target="_blank">Entrez</a></span>系统增加新特征</h3>
<p>在2009年<a href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi&amp;part=feb09" target="_blank">3月</a>和<a href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi&amp;part=Mar09" target="_blank">4月</a>份的<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="NCBI" target="_blank">NCBI</a></span> NEWS 分别有提到了<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>系统新的一些特征面貌。此次改版后，在文献和<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/entrez/" title="序列" target="_blank">序列</a></span>数据库，栓索的结果增加了一些相关的和可能感兴趣的链接，更加有利于用户的检索，更容易搜到期望的结果。</p>
<p>这些新的扩展组件叫做<strong>discovery components</strong>，主要有三种类别：<strong>Sensors</strong>, <strong>Database Ads</strong>, 和<strong>Analysis Tools</strong>。</p>
<p>Sensors组件在搜索的同时提供一种潜在的更加相关的结果以供选择。对<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/832/" title="PubMed" target="_blank">PubMed</a></span>数据库而言，<strong>Citation Sensor</strong>是当用户在PubMed数据库搜索文献时显示的；<strong><span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/accession/" title="Accession" target="_blank">Accession</a></span> Sensor</strong>是用户在PubMed数据库搜索序列数据库相关的数据库显示的，提供在序列数据库的搜索结果；还有一个<strong>Hot Topic Sensor</strong>，也是在PubMed数据库栓索结果中显示的，例如最近显示是有关H1N1的一些信息。这个是经常改变的，以当前的热门话题为参考。<strong>Gene Sensor</strong>，精确匹配和显示Gene数据库的结果，开始只在PubMed数据库试用，现在protein 和 nucleotide 数据库一样支持。<span id="more-685"></span></p>
<p><strong>Database Ads</strong>组件，显示其它数据库的相关信息链接。新的Database Ads，更加强调显示PubMed Central数据库的全文文献。像一些3D结构数据库、流行感病毒的<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/genome/" title="基因组" target="_blank">基因组</a></span>、SARS、HIV等的相关接也出现在检索结果。</p>
<p><strong>Analysis Tools</strong>，提供一些相关工具的链接，是非常有用的。像检索序列时直接一键链接到<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/blast/" title="Blast" target="_blank">Blast</a></span>分析、3D结构分析、蛋白结构域等。</p>
<h3>Sensors</h3>
<p>上面已经提到，Sensors分为四类：<strong>the Citation Sensor, the Accession Sensor, the Hot Topic Sensor</strong>, 和 <strong>the new Gene Sensor</strong>。</p>
<p>例如在PubMed数据库搜索“Lander 2001 Nature”，在最顶端的会显示一个<strong>Citation Sensor</strong>更加精确匹配搜索的关键词。看下图。</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Citation-Sensor.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-full wp-image-686" title="Citation Sensor" src="http://liucheng.name/wp-content/uploads/2009/06/Citation-Sensor.png" alt="Citation Sensor" width="599" height="351" /></a></p>
<p>例如在PubMed数据库搜索基因相关的名称，就会显示<strong>Gene Sensor</strong>，提供链接到Gene数据库的组件。看下图。</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Gene-Sensor2.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-full wp-image-687" title="Gene Sensor2" src="http://liucheng.name/wp-content/uploads/2009/06/Gene-Sensor2.png" alt="Gene Sensor2" width="537" height="332" /></a></p>
<p>例如在protein数据库搜索某个基因的序列，只要在Gene数据库能匹配上，就会显示<strong>Gene Sensor</strong>，提供链接到Gene数据库的组件。看下图。</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Gene-Sensor.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-full wp-image-688" title="Gene Sensor" src="http://liucheng.name/wp-content/uploads/2009/06/Gene-Sensor.png" alt="Gene Sensor" width="525" height="252" /></a></p>
<p>例如在PubMed数据库搜索序列Accession，一般在PubMed数据库不一定有，但也显示一个<strong>Accession Sensor</strong>，链接到GenBank数据库。看下图</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Accession-Sensor.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-full wp-image-689" title="Accession Sensor" src="http://liucheng.name/wp-content/uploads/2009/06/Accession-Sensor.png" alt="Accession Sensor" width="623" height="157" /></a></p>
<h3>Database Ads</h3>
<p>Hot Topic Sensor和Database Ads如下图所示：</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Database-Ads2.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-full wp-image-690" title="Database Ads2" src="http://liucheng.name/wp-content/uploads/2009/06/Database-Ads2.png" alt="Database Ads2" width="445" height="229" /></a></p>
<h3>Analysis Tools</h3>
<p>Hot Topic Sensor和Analysis Tools如下图所示：</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/Analysis-Tools.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-medium wp-image-691" title="Analysis Tools" src="http://liucheng.name/wp-content/uploads/2009/06/Analysis-Tools-300x154.png" alt="Analysis Tools" width="300" height="154" /></a></p>
<h3>其它</h3>
<p>如在序列的显示页面，改变原先的外观，显示其它格式的方法等。还增加了该基因相关的文献和相关的链接。如下图。</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/06/genbank.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-medium wp-image-692" title="Entrez系统扩展组件更有利于检索" src="http://liucheng.name/wp-content/uploads/2009/06/genbank-300x111.png" alt="Entrez系统扩展组件更有利于检索" width="300" height="111" /></a></p>
<p> </p>
<p><span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="查看 NCBI 中的全部文章" target="_blank">NCBI</a></span>的<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>系统，所有这些discovery components的改进，旨在为了给用户提供一个更加完善的检索体验。用户只需动动鼠标，只能找到所有相关的结果。（<span class='wp_keywordlink'><a href="http://liucheng.name/" title="柳城博客" target="_blank">柳城博客</a></span>/编译，<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi-news/" title="查看 NCBI News 中的全部文章" target="_blank">NCBI News</a></span>, June 2009）</p>
<p>更多功能，等着你来体验！！</p>
<h3>原文检索:</h3>
<p><a href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi&amp;part=JFKPFT637.bid.1#JFKPFT637.Featured1_1">http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi&amp;part=JFKPFT637.bid.1#JFKPFT637.Featured1_1</a></p>
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		<pubDate>Fri, 19 Jun 2009 08:54:11 +0000</pubDate>
		<dc:creator>柳城</dc:creator>
				<category><![CDATA[生物信息学]]></category>
		<category><![CDATA[Entrez]]></category>
		<category><![CDATA[NCBI]]></category>

		<guid isPermaLink="false">http://www.liucheng.name/?p=684</guid>
		<description><![CDATA[Entrez是面向生物学家的数据库查询系统，其特点之一是使用十分方便。它把序列、结构、文献、基因组、系统分类等不同类型的数据库有机地结合在一起，通过超文本链接，用户可以从一个数据库直接转入另一个数据库。Entrez的另一个特点是把数据..<table class="wumii-related-items" cellspacing="0" cellpadding="3" border="0"  style="clear: both;">
    
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			<content:encoded><![CDATA[<p><span class='wp_keywordlink'><a href="http://liucheng.name/entrez/" title="Entrez" target="_blank">Entrez</a></span>是面向生物学家的数据库查询系统，其特点之一是使用十分方便。它把<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/entrez/" title="序列" target="_blank">序列</a></span>、结构、文献、<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/genome/" title="基因组" target="_blank">基因组</a></span>、系统分类等不同类型的数据库有机地结合在一起，通过超文本链接，用户可以从一个数据库直接转入另一个数据库。</p>
<p><span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="NCBI" target="_blank">NCBI</a></span>所有数据库<br />
<a href="http://www.ncbi.nlm.nih.gov/sites/gquery">http://www.ncbi.nlm.nih.gov/sites/gquery</a><span id="more-684"></span><br />
<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>的另一个特点是把数据库和应用程序结合在一起。例如，通过“Related sequence”工具，可以直接找到与查询所得蛋白质序列同源的其它蛋白质。查询得到的蛋白质三维结构，可以通过在用户计算机上安装的Cn3D软件直接显示分子图形。</p>
<p><span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>系统的开发基于特殊的数据模型<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="查看 NCBI 中的全部文章" target="_blank">NCBI</a></span> ANS.1 (Abstract Syntax Notation)，在对于文献摘要中的关键词查询时，不仅考虑了查询对象和数据库中单词的实际匹配，而且考虑了意义相近的匹配。在查询文献数据库摘要得到结果后，可以通过点击“Related Articles”继续查找相关文献。</p>
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		<title>Entrez所有数据库的最新数据统计</title>
		<link>http://liucheng.name/429/</link>
		<comments>http://liucheng.name/429/#comments</comments>
		<pubDate>Mon, 04 May 2009 09:21:25 +0000</pubDate>
		<dc:creator>柳城</dc:creator>
				<category><![CDATA[每周精选]]></category>
		<category><![CDATA[生物信息学]]></category>
		<category><![CDATA[Entrez]]></category>
		<category><![CDATA[数据库]]></category>
		<category><![CDATA[数据统计]]></category>

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		<description><![CDATA[Entrez总共有35个数据库,包括 NCBI的站点内容和FTP的内容等。通过all[filter]命令就能查到所有数据库最新的数据记录。<table class="wumii-related-items" cellspacing="0" cellpadding="3" border="0"  style="clear: both;">
    
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			<content:encoded><![CDATA[<p><span class='wp_keywordlink'><a href="http://liucheng.name/entrez/" title="Entrez" target="_blank">Entrez</a></span>总共有35个<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/databank/" title="查看 数据库 中的全部文章" target="_blank">数据库</a></span>,包括 <span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="NCBI" target="_blank">NCBI</a></span>的站点内容和FTP的内容等。通过all[filter]命令就能查到所有<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/databank/" title="查看 数据库 中的全部文章" target="_blank">数据库</a></span>最新的数据记录。常用的数据库有（统计时间：2009/05/04）：<br />
Pubmed：        18832968个记录；<br />
Nucleotide： 76750026个记录；<br />
Protein：         26369028个记录；<br />
Gene：              5798947个记录；<br />
UniGene：      3633531个记录；<span id="more-429"></span></p>
<p>详细请看下图：</p>
<p style="text-align: center;"><a href="http://liucheng.name/wp-content/uploads/2009/05/entrez.png" class="highslide-image" onclick="return hs.expand(this);"><img class="aligncenter size-medium wp-image-428" title="entrez" src="http://liucheng.name/wp-content/uploads/2009/05/entrez-300x206.png" alt="entrez" width="300" height="206" /></a></p>
<p>查看最新统计的链接：<a href="http://www.ncbi.nlm.nih.gov/sites/gquery?term=all%5Bfilter%5D">http://www.ncbi.nlm.nih.gov/sites/gquery?term=all%5Bfilter%5D</a></p>
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		<item>
		<title>中文Entrez序列查询界面</title>
		<link>http://liucheng.name/358/</link>
		<comments>http://liucheng.name/358/#comments</comments>
		<pubDate>Fri, 17 Apr 2009 14:50:40 +0000</pubDate>
		<dc:creator>柳城</dc:creator>
				<category><![CDATA[生物信息学]]></category>
		<category><![CDATA[Entrez]]></category>
		<category><![CDATA[序列]]></category>
		<category><![CDATA[生物信息软件]]></category>

		<guid isPermaLink="false">http://www.liucheng.name/?p=358</guid>
		<description><![CDATA[所以今天我弄了一个简单的序列查询界面。只要输入Accession Number 或 GI Number 就能返回序列，可以选择GenBank格式或Fasta格式。
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			<content:encoded><![CDATA[<p>最近经常泡<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/ncbi/" title="NCBI" target="_blank">NCBI</a></span>，头都痛了。不过，还是学到了一些东西的。<br />
看了一些NCBI的PowerScripting，太复杂了，目前只能看懂了一些。也下载了一些教程，无奈头痛呀，好多看不明白。<br />
虽然如此，成果还是有一些的。也不枉这几天的学习。<br />
了解PowerScripting之后，发觉这套系统真是太强大了。不可思议呀。真想马上学会。<span id="more-358"></span></p>
<p>浏览了一遍之后，我就有一个想法，弄一个中文的<span class='wp_keywordlink'><a href="http://liucheng.name/entrez/" title="Entrez" target="_blank">Entrez</a></span><span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/entrez/" title="序列" target="_blank">序列</a></span>查询界面，把<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/%e5%ba%8f%e5%88%97/" title="查看 序列 中的全部文章" target="_blank">序列</a></span>查询变得更简单。当然了，这是因为借助了NCBI强大的工具的。<br />
所以今天我弄了一个简单的<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/%e5%ba%8f%e5%88%97/" title="查看 序列 中的全部文章" target="_blank">序列</a></span>查询界面。<br />
只要输入<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/accession/" title="Accession" target="_blank">Accession</a></span> Number 或 GI Number 就能返回序列，可以选择GenBank格式或<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/770/" title="Fasta" target="_blank">Fasta</a></span>格式。<br />
这个查询的强大之处还在于可以查到旧的版本序列。真是太令人兴奋了。</p>
<p>中文<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>序列查询：<a href="http://www.liucheng.name/entrez/" target="_blank">http://www.liucheng.name/entrez/</a></p>
<p>希望以后有时间慢慢更新，让查询系统变得更强大。因为目前PowerScripting还是有许多看不明白的。</p>
<p>如果你有什么问题或建议，欢迎一起探讨。</p>
<p>如果你有什么要求，或是希望增加那些功能，也可以留言。我努力去实现，可以的话。呵呵</p>
<p>好了。希望有更多感兴趣的朋友一起来交流。</p>
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		<title>NCBI:Entrez数据库及相互关系模型图</title>
		<link>http://liucheng.name/353/</link>
		<comments>http://liucheng.name/353/#comments</comments>
		<pubDate>Thu, 16 Apr 2009 04:59:06 +0000</pubDate>
		<dc:creator>柳城</dc:creator>
				<category><![CDATA[每周精选]]></category>
		<category><![CDATA[生物信息学]]></category>
		<category><![CDATA[Entrez]]></category>
		<category><![CDATA[NCBI]]></category>
		<category><![CDATA[模型图]]></category>

		<guid isPermaLink="false">http://www.liucheng.name/?p=353</guid>
		<description><![CDATA[Model of Entrez Databases：模型图显示了Entrez各个数据库及各个数据库之间的相互关系。圆形表示每个数据库，不同的颜色代表了数据库大概的记录数。当鼠标放在圆圈上面时，将会显示与该数据库相关的其它数据库，并指出两个数据库间有多少个链接数存在。<table class="wumii-related-items" cellspacing="0" cellpadding="3" border="0"  style="clear: both;">
    
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                        <font size="-1" color="#333333" style="display: block !important; line-height: 15px !important; width: 102px !important; font: 12px/15px arial !important; height: 60px !important; margin: 3px 0 0 0 !important; padding: 0 !important; overflow: hidden !important;">NCBI Entrez系统简介</font>
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</table>]]></description>
			<content:encoded><![CDATA[<p>Model of <span class='wp_keywordlink'><a href="http://liucheng.name/entrez/" title="Entrez" target="_blank">Entrez</a></span> Databases<br />
<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/model-map/" title="查看 模型图 中的全部文章" target="_blank">模型图</a></span>显示了<span class='wp_keywordlink_affiliate'><a href="http://liucheng.name/tag/entrez/" title="查看 Entrez 中的全部文章" target="_blank">Entrez</a></span>各个数据库及各个数据库之间的相互关系。圆形表示每个数据库，不同的颜色代表了数据库大概的记录数。当鼠标放在圆圈上面时，将会显示与该数据库相关的其它数据库，并指出两个数据库间有多少个链接数存在。<br />
<span id="more-353"></span></p>
<p><img class="ngg-singlepic ngg-center" src="http://www.liucheng.name/wp-content/gallery/200904/model-of-entrez-databases.jpg" alt="model-of-entrez-databases.jpg" /></p>
<p>需要Flash播放器。</p>
<p><object width="600" height="545" data="http://www.ncbi.nlm.nih.gov/Database/datamodel/data_nodes.swf" type="application/x-shockwave-flash"><param name="src" value="http://www.ncbi.nlm.nih.gov/Database/datamodel/data_nodes.swf" /></object></p>
<p>原文链接：<a href="http://www.ncbi.nlm.nih.gov/Database/datamodel/index.html">http://www.ncbi.nlm.nih.gov/Database/datamodel/index.html</a></p>
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