MoKCa:癌症相关突变激酶信息数据库

当人类罹患癌症时,蛋白激酶家族成员是发生基因突变最多的一类基因。这些发生突变的激酶基因和被激活的激酶基因也是抗癌治疗最有效的作用靶点。

MoKCa数据库http://strubiol.icr.ac.uk/extra/mokca)是一个有关癌症相关突变激酶信息的数据库,库中收录了大量与突变激酶基因相关的结构注释信息和功能注释信息,以及当这些激酶发生突变时会产生怎样的结果的预测信息。肿瘤组织和肿瘤细胞系体细胞突变数据被标记在相应的蛋白质晶体结构域上。在蛋白质结构域象形图上以及蛋白质3D结构图上还对发生突变的氨基酸位点进行了突出标记。

此外,在网页上还会显示与每一个突变有关的数据以及与该突变分子功能有关的专业注释信息。MoKCa数据库就是将蛋白质资源与功能注释资源相结合,并且加上例如结构域或磷酸化位点等结构和功能方面的注释信息,以此打造一个收录了每一个潜在的癌症相关突变激酶以及伴有权威肿瘤生物学家和结构生物学家注释信息的数据库。

Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer therapies. The MoKCa database (Mutations of Kinases in Cancer) has been developed to structurally and functionally annotate, and where possible predict, the phenotypic consequences of mutations in protein kinases implicated in cancer.

MoKCa:癌症相关突变激酶信息数据库

Protein kinases are a group of proteins that add phosphate groups to proteins. There are over 500 documented mammalian protein kinases encoded in the human genome, which together represent the largest family of human enzymes, collectively termed the kinome. They play indispensable roles in numerous cellular, metabolic and signalling pathways, in all cell types.

For further information about Mokca, see our publication in Nucleic Acids Research, available as a free-access PDF.