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SMART入门,蛋白结构和功能分析

SMART入门,蛋白结构和功能分析

SMART介绍

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures. More than 500 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa. For all the details, please refer to the publications on SMART.

SMART(http://smart.embl-heidelberg.de/),可以说是蛋白结构预测和功能分析的工具集合。简单点说,就是集合了一些工具,可以预测蛋白的一些二级结构。如跨膜区(Transmembrane segments),复合螺旋区(coiled coil regions),信号肽(Signal peptides),蛋白结构域(PFAM domains)等。 阅读更多

SWISS-MODEL同源建模快速入门

以下是对SWISS-MODEL(http://swissmodel.expasy.org),一个同源建模服务器和已注释的蛋白质三维结构同源模型的知识库的介绍。

本指南帮助读者快速浏览SWISS-MODEL的功能。我们希望读者已经掌握了关于蛋白质结构和同源建模方法的基础知识。 阅读更多