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三种分析蛋白结构域(Domains)的方法

三种分析蛋白结构域(Domains)的方法

1,SMART入门,蛋白结构和功能分析

详细: http://www.liucheng.name/?p=738

2,Sanger的Pfam数据库

网址:http://pfam.sanger.ac.uk/

目前的版本:Pfam 23.0 (July 2008, 10340 families)

The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs). 阅读更多

SMART入门,蛋白结构和功能分析

SMART入门,蛋白结构和功能分析

SMART介绍

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures. More than 500 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa. For all the details, please refer to the publications on SMART.

SMART(http://smart.embl-heidelberg.de/),可以说是蛋白结构预测和功能分析的工具集合。简单点说,就是集合了一些工具,可以预测蛋白的一些二级结构。如跨膜区(Transmembrane segments),复合螺旋区(coiled coil regions),信号肽(Signal peptides),蛋白结构域(PFAM domains)等。 阅读更多

orf-finder-1

ORF Finder使用说明及基因预测

ORF Finder  是一个图形的序列分析工具,分析并找到序列的ORF区(开放读码框架),这个工具使用标准的或其它特殊的遗传密码子列出所有可能的ORF区,并推导出氨基酸序列。

在线网址:http://www.ncbi.nlm.nih.gov/gorf/gorf.html 阅读更多